Identifying proteins that regulate immune responses in a type of blood vessel inflammation
Official title: Molecular Imaging to Identify Regulators of G-protein Signaling Proteins in Human Neutrophils and Their Role in Vasculitis
Funded at Massachusetts General Hospital · NIH-11036974 · Data updated 2026-11-12
This study is looking at how certain proteins affect the immune system in people with ANCA vasculitis, a serious autoimmune disease, to find ways to predict flare-ups and personalize treatments just for you.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 15, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $80,995 |
| NIH project number | 1R03AI188350-01 |
| Project ID | NIH-11036974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ANCA vasculitis who are experiencing disease symptoms or relapses.
✕Less likely to help
Patients with other forms of vasculitis or autoimmune diseases unrelated to ANCA may not benefit from this research.
What this research studies
This research investigates the role of specific proteins in regulating immune cell responses in patients with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis, a serious autoimmune disease. The study aims to understand how these proteins interact with signaling pathways that influence inflammation and disease progression. By using advanced molecular imaging techniques, researchers will explore the mechanisms behind neutrophil activation and their contribution to the disease. The goal is to identify potential biomarkers that could help predict disease relapse and tailor treatments for individual patients.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting disease relapse and more effective, personalized treatment strategies for patients with ANCA vasculitis.
How similar studies have gone: Previous research has shown promise in understanding the role of immune signaling pathways in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Schmider, Angela Bair — Massachusetts General Hospital
- Study coordinator: Schmider, Angela Bair
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.