Identifying proteins that regulate immune responses in a type of blood vessel inflammation
Molecular Imaging to Identify Regulators of G-protein Signaling Proteins in Human Neutrophils and Their Role in Vasculitis
This study is looking at how certain proteins affect the immune system in people with ANCA vasculitis, a serious autoimmune disease, to find ways to predict flare-ups and personalize treatments just for you.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11036974 on NIH RePORTER |
What this research studies
This research investigates the role of specific proteins in regulating immune cell responses in patients with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis, a serious autoimmune disease. The study aims to understand how these proteins interact with signaling pathways that influence inflammation and disease progression. By using advanced molecular imaging techniques, researchers will explore the mechanisms behind neutrophil activation and their contribution to the disease. The goal is to identify potential biomarkers that could help predict disease relapse and tailor treatments for individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ANCA vasculitis who are experiencing disease symptoms or relapses.
Not a fit: Patients with other forms of vasculitis or autoimmune diseases unrelated to ANCA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting disease relapse and more effective, personalized treatment strategies for patients with ANCA vasculitis.
How similar studies have performed: Previous research has shown promise in understanding the role of immune signaling pathways in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Schmider, Angela Bair — Massachusetts General Hospital
- Study coordinator: Schmider, Angela Bair
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.