Identifying proteins that help maintain movement and cognitive function in Alzheimer's disease
Identifying resilience proteins in key motor tissues that drive motor and cognitive decline and offset the negative effects of ADRD pathologies within and outside the brain
['FUNDING_R01'] · RUSH UNIVERSITY MEDICAL CENTER · NIH-11032817
This study is looking at how certain proteins in the muscles and brain might help older adults with Alzheimer's disease and related conditions stay active and think clearly, with the hope of finding ways to support their movement and mental health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUSH UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11032817 on ClinicalTrials.gov |
What this research studies
This research investigates how certain proteins in key motor tissues can help maintain movement and cognitive function in individuals affected by Alzheimer's disease and related dementias (ADRD). By examining the differences in motor resilience among older adults with similar levels of Alzheimer’s pathologies, the study aims to identify specific proteins that may protect against the decline in movement and cognitive abilities. The researchers will use advanced techniques to analyze these proteins and their potential roles in promoting resilience against the negative effects of ADRD. This work could lead to new insights into how to support better movement and cognitive health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults diagnosed with Alzheimer's disease or related dementias who exhibit varying degrees of motor and cognitive decline.
Not a fit: Patients who do not have Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance movement and cognitive resilience in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in identifying resilience factors in cognitive health, suggesting that this approach may yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- RUSH UNIVERSITY MEDICAL CENTER — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCHMAN, ARON S — RUSH UNIVERSITY MEDICAL CENTER
- Study coordinator: BUCHMAN, ARON S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome