Identifying proteins affected by tyrosine phosphatases in cancer cells
A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
This study is looking at how certain enzymes affect cancer by changing proteins in our cells, and it aims to find out which proteins these enzymes interact with, which could help us understand cancer better and lead to new treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10893310 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain enzymes, known as tyrosine phosphatases, influence cancer development by modifying proteins in cells. The team aims to develop a new method that combines advanced protein engineering and mass spectrometry to identify the specific proteins that these enzymes act upon in live cells. By uncovering these interactions, the research hopes to shed light on the role of tyrosine phosphatases in cancer signaling and potentially lead to new therapeutic targets. Patients may benefit from this work as it could enhance our understanding of cancer mechanisms and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cancers that may be influenced by tyrosine phosphatase activity.
Not a fit: Patients with cancers unrelated to tyrosine phosphorylation mechanisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and the development of targeted therapies for patients.
How similar studies have performed: While the approach of identifying enzyme substrates is established, the specific focus on tyrosine phosphatases in live cells represents a novel and untested strategy.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Shah, Neel H — Columbia Univ New York Morningside
- Study coordinator: Shah, Neel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.