Identifying proteins affected by tyrosine phosphatases in cancer cells
Official title: A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
Funded at Columbia Univ New York Morningside · NIH-10893310 · Data updated 2026-11-12
This study is looking at how certain enzymes affect cancer by changing proteins in our cells, and it aims to find out which proteins these enzymes interact with, which could help us understand cancer better and lead to new treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $183,919 |
| NIH project number | 5R61CA278452-02 |
| Project ID | NIH-10893310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cancers that may be influenced by tyrosine phosphatase activity.
✕Less likely to help
Patients with cancers unrelated to tyrosine phosphorylation mechanisms may not benefit from this research.
What this research studies
This research focuses on understanding how certain enzymes, known as tyrosine phosphatases, influence cancer development by modifying proteins in cells. The team aims to develop a new method that combines advanced protein engineering and mass spectrometry to identify the specific proteins that these enzymes act upon in live cells. By uncovering these interactions, the research hopes to shed light on the role of tyrosine phosphatases in cancer signaling and potentially lead to new therapeutic targets. Patients may benefit from this work as it could enhance our understanding of cancer mechanisms and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer biology and the development of targeted therapies for patients.
How similar studies have gone: While the approach of identifying enzyme substrates is established, the specific focus on tyrosine phosphatases in live cells represents a novel and untested strategy.
Where this research is happening
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Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Shah, Neel H — Columbia Univ New York Morningside
- Study coordinator: Shah, Neel H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.