Identifying protein markers to predict pain outcomes after pancreas removal surgery
Official title: Protein biomarkers to predict pain outcomes after total pancreatectomy with islet autotransplant
Funded at University of Minnesota · NIH-10932990 · Data updated 2026-11-12
This study is looking at how certain proteins in blood and urine can help doctors understand which kids having surgery for chronic pancreatitis will feel better afterward and which ones might still have pain, so they can provide the best care possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 22, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $706,314 |
| NIH project number | 5R01DK138809-02 |
| Project ID | NIH-10932990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are suffering from chronic pancreatitis and are considering total pancreatectomy with islet autotransplantation.
✕Less likely to help
Patients who are not undergoing total pancreatectomy or those with other unrelated pain conditions may not benefit from this research.
What this research studies
This research investigates how specific protein biomarkers can help predict pain outcomes in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) due to chronic pancreatitis. By analyzing blood and urine samples from patients before and after the surgery, the study aims to identify which patients are likely to experience significant pain relief and which may continue to suffer from pain. The research utilizes a large database from a multicenter study to enhance the understanding of pain responses related to this surgical procedure.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of pain outcomes for patients undergoing pancreas removal surgery, ultimately improving their quality of life.
How similar studies have gone: Previous research has shown promise in using biomarkers to predict pain outcomes in similar surgical contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Bellin, Melena D. — University of Minnesota
- Study coordinator: Bellin, Melena D.
Related research
Other NIH-funded projects on the same topics.
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Biomarkers to forecast pain relief after total pancreatectomy with islet autotransplant
Scientists are testing blood and urine markers to predict which patients will have less pain after having their pancreas removed and insulin-producing tissue transplanted back, helping children and others with chronic pancreatitis plan better.
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Protein markers to help predict pain after pancreas removal with islet autotransplant
This will look for proteins in blood or urine that help tell which people with chronic pancreatitis may get pain relief after removing the pancreas and transplanting their own islets.
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Investigating long-term islet function after total pancreatectomy with islet autotransplantation
This study is looking at people who have had surgery to remove their pancreas and then had their insulin-producing cells put back in, to see how well those cells work over time and how it affects their blood sugar and diabetes, so we can find better ways to help them manage their health.
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Pancreatic Surgery and New Diabetes Risk in Adults without Diabetes
This study tests whether removing part or all of the pancreas during surgery affects blood sugar control and metabolism in adults who did not have diabetes before the operation.
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PancreasPlus app for monitoring recovery, symptoms, and education after pancreatic cancer treatment
This project will test whether the PancreasPlus app helps adults with pancreatic cancer and their caregivers monitor symptoms, get timely information, and communicate with their healthcare team.
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Hybrid Closed-Loop Insulin Delivery After Pancreatectomy
This study tests whether a commercially available monohormonal hybrid closed-loop insulin delivery system can help adults who developed diabetes after pancreatectomy better manage blood sugar.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.