Identifying protein markers to predict pain outcomes after pancreas removal surgery
Protein biomarkers to predict pain outcomes after total pancreatectomy with islet autotransplant
This study is looking at how certain proteins in blood and urine can help doctors understand which kids having surgery for chronic pancreatitis will feel better afterward and which ones might still have pain, so they can provide the best care possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10932990 on NIH RePORTER |
What this research studies
This research investigates how specific protein biomarkers can help predict pain outcomes in children undergoing total pancreatectomy with islet autotransplantation (TPIAT) due to chronic pancreatitis. By analyzing blood and urine samples from patients before and after the surgery, the study aims to identify which patients are likely to experience significant pain relief and which may continue to suffer from pain. The research utilizes a large database from a multicenter study to enhance the understanding of pain responses related to this surgical procedure.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are suffering from chronic pancreatitis and are considering total pancreatectomy with islet autotransplantation.
Not a fit: Patients who are not undergoing total pancreatectomy or those with other unrelated pain conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of pain outcomes for patients undergoing pancreas removal surgery, ultimately improving their quality of life.
How similar studies have performed: Previous research has shown promise in using biomarkers to predict pain outcomes in similar surgical contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Bellin, Melena D. — University of Minnesota
- Study coordinator: Bellin, Melena D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.