Identifying protein markers linked to delirium and cognitive decline in older heart surgery patients
Proteomic Signatures of Delirium and Longterm Cognitive Decline in Older Cardiac Surgical Patients
This study is looking at how certain proteins in the blood might help us understand which older patients are more likely to experience confusion or memory problems after heart surgery, so we can find ways to better support those at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11108056 on NIH RePORTER |
What this research studies
This research investigates the relationship between specific proteins and the risk of developing delirium and long-term cognitive decline in older patients undergoing cardiac surgery. By analyzing blood samples from patients, the study aims to identify biomarkers that can predict which individuals are at higher risk for these complications. The approach includes utilizing advanced proteomic technology to assess changes in protein levels before and after surgery, allowing for targeted interventions to improve patient outcomes. The findings could lead to better preoperative assessments and tailored treatments for at-risk patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are scheduled for cardiac surgery.
Not a fit: Patients under the age of 65 or those not undergoing cardiac surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and management of older patients at risk for delirium and cognitive decline after cardiac surgery.
How similar studies have performed: Previous research has shown promising results in identifying biomarkers for delirium and cognitive decline, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Subramaniam, Balachundhar — Beth Israel Deaconess Medical Center
- Study coordinator: Subramaniam, Balachundhar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.