Identifying protein markers linked to brain changes in Lewy body dementia
Novel Protein Biomarkers of Corticolimbic Pathophysiology in Lewy body Dementia
This study is looking at how changes in certain proteins in the brain and body fluids can help us understand Lewy body dementia better, with the goal of finding new ways to diagnose and track the disease, and patients can join a registry to support this important research.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10896269 on NIH RePORTER |
What this research studies
This research investigates the underlying brain changes in Lewy body dementia (LBD) by identifying unique protein signatures in cerebrospinal fluid and plasma. The study focuses on understanding how alterations in neuronal and non-neuronal pathways contribute to cognitive and neuropsychiatric decline in patients with LBD. By utilizing a network-based proteomic approach, researchers aim to develop biomarkers that can help diagnose and monitor the progression of this condition. Patients may have the opportunity to contribute to a registry that supports ongoing research in this area.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body dementia, including those with Parkinson’s disease dementia and dementia with Lewy bodies.
Not a fit: Patients with other forms of dementia or cognitive decline unrelated to Lewy body pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective biomarkers for diagnosing and monitoring Lewy body dementia, potentially improving patient care.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for other neurodegenerative diseases, suggesting that this approach may yield valuable insights for Lewy body dementia as well.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Seyfried, Nicholas Thomas — Emory University
- Study coordinator: Seyfried, Nicholas Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.