Identifying protein markers for Alzheimer's disease and related dementias
Plasma Proteomic Signatures for Alzheimer's Disease and Related Dementias
This study is looking at blood samples from women to find specific proteins that might help us spot early signs of Alzheimer's disease and understand how it works, with the hope of discovering new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10524420 on NIH RePORTER |
What this research studies
This research aims to uncover molecular signatures in the blood that are associated with Alzheimer's disease (AD) and related dementias. By analyzing plasma proteins from a large cohort of women, the study seeks to detect early signs of AD and understand its biological mechanisms. Using advanced proteomics technology, researchers will measure thousands of proteins to identify potential biomarkers that could lead to new therapeutic targets. The study leverages extensive longitudinal data and preserved biospecimens from the Women's Health Initiative Memory Study.
Who could benefit from this research
Good fit: Ideal candidates for this research include women who are at risk for Alzheimer's disease, particularly those with a family history or early cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those not participating in the Women's Health Initiative Memory Study may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better treatment options for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for Alzheimer's disease using proteomic approaches, indicating that this methodology has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Shadyab, Aladdin — University of California, San Diego
- Study coordinator: Shadyab, Aladdin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.