Identifying protein changes linked to cancer and inflammatory diseases
Steric-free labeling strategies to study disease-related non-histone substrates of post-translational modifications
This project is developing new chemical tools to find specific changes in proteins that play a role in diseases like cancer and inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11090640 on NIH RePORTER |
What this research studies
This research focuses on understanding how proteins in our bodies change, specifically through processes called acetylation and O-GlcNAcylation. These changes can affect how proteins work and are linked to serious conditions like cancer and inflammatory diseases. We are developing special chemical methods using fluorine to precisely mark and study these protein changes. By identifying these modified proteins and how they interact, we hope to uncover new targets for future medicines. This work could lead to more effective treatments for challenging diseases.
Who could benefit from this research
Good fit: This foundational chemical biology work does not directly involve patient participation at this stage, but future clinical applications would target patients with specific cancers or inflammatory disorders.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new protein targets for developing more selective and effective treatments for cancer and inflammatory diseases.
How similar studies have performed: While the general concept of studying protein modifications is established, this project proposes novel fluorine-based chemical labeling strategies to identify previously unknown disease-related proteins.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Wang, Ross — Temple Univ of the Commonwealth
- Study coordinator: Wang, Ross
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.