Identifying protective antibodies against group A streptococcal infections
Official title: Protective antibody in streptococcal infection models
Funded at New York Medical College · NIH-10747980 · Data updated 2026-11-12
This study is looking at how certain antibodies can help protect against group A strep infections by finding out which parts of the bacteria trigger a strong immune response, and it’s for anyone interested in a potential new vaccine that could keep kids and adults safe from different strains of this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Medical College NIH-funded |
| Lab location | 1 site (Valhalla, United States) |
| Project start | December 2, 2022 |
| Project end | November 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $599,556 |
| NIH project number | 5R01AI173565-02 |
| Project ID | NIH-10747980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children who are at risk of GAS infections and adults who have developed protective antibodies.
✕Less likely to help
Patients who have already been vaccinated against GAS or those with existing GAS infections may not benefit from this research.
What this research studies
This research investigates how antibodies can prevent group A streptococcal (GAS) infections by identifying specific antigens that trigger protective immune responses. The study involves analyzing serum samples from children and adults to understand the presence of protective antibodies. By using immunodeficient mice, the researchers will test the effectiveness of these antibodies against low doses of GAS, aiming to develop a multicomponent vaccine that could provide broad protection against various GAS strains.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that significantly reduces the incidence of group A streptococcal infections in children.
How similar studies have gone: Previous research has shown promise in developing vaccines targeting similar bacterial infections, indicating potential success for this approach.
Where this research is happening
-
New York Medical College
Valhalla, United States Active
Researchers
- Principal investigator: Bessen, Debra E — New York Medical College
- Study coordinator: Bessen, Debra E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.