Identifying patients with diabetes at high risk of kidney failure
Development of Prognostic Algorithms to Identify Subjects at High Risk of ESKD in Type 2 Diabetes
This study is looking to find better ways to identify people with type 2 diabetes who might be at risk for serious kidney problems by examining certain proteins in their blood, which could help doctors take action sooner to prevent complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10911168 on NIH RePORTER |
What this research studies
This research focuses on developing algorithms to identify individuals with type 2 diabetes who are at high risk for end-stage kidney disease (ESKD). By analyzing serum proteins associated with kidney function loss, researchers aim to enhance existing predictive models that currently rely on glomerular filtration rate (GFR) and albuminuria. The study will utilize data from established cohorts to validate these biomarkers and improve risk prediction for patients. This could lead to earlier interventions for those at risk, potentially preventing severe kidney complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 2 diabetes, particularly those showing early signs of kidney dysfunction.
Not a fit: Patients without diabetes or those who do not exhibit any risk factors for kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier identification and intervention for patients with diabetes at risk of kidney failure, improving their long-term health outcomes.
How similar studies have performed: Previous research has successfully identified biomarkers for kidney disease risk in diabetes, suggesting that this approach has potential for meaningful advancements.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: Krolewski, Andrzej S — Joslin Diabetes Center
- Study coordinator: Krolewski, Andrzej S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.