Identifying patients who will respond to specific breast cancer treatments using a biomarker.
Tyrosine phosphorylation of p27Kip1 as a biomarker to identify Cdk4/6 inhibitor response
This study is looking to find a way to tell which women with metastatic breast cancer will benefit from a specific type of treatment called CDK4/6 inhibitors, so they can get the most effective care and avoid treatments that might not work for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Suny Downstate Medical Center NIH-funded |
| Lab location | 1 site (Brooklyn, United States) |
| Project ID | NIH-10852924 on NIH RePORTER |
What this research studies
This research focuses on developing a biomarker that can identify which patients with metastatic breast cancer will respond to CDK4/6 inhibitors, a class of drugs that has shown promise in treatment. By analyzing the tyrosine phosphorylation of p27Kip1, the study aims to pinpoint patients who are likely to benefit from these therapies, thereby avoiding ineffective treatments and reducing the need for chemotherapy. The goal is to enhance patient outcomes by ensuring that the right patients receive the right drugs at the right time, potentially expanding the use of these therapies to other cancer types as well.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with metastatic hormone receptor-positive breast cancer who are considering treatment with CDK4/6 inhibitors.
Not a fit: Patients with early-stage breast cancer or those whose cancer is not hormone receptor-positive may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with metastatic breast cancer.
How similar studies have performed: Other research has shown promise in developing biomarkers for cancer treatment responsiveness, indicating that this approach has potential for success.
Where this research is happening
Brooklyn, United States
- Suny Downstate Medical Center — Brooklyn, United States (Active)
Researchers
- Principal investigator: Brissette, Janice L — Suny Downstate Medical Center
- Study coordinator: Brissette, Janice L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.