Identifying patients who benefit most from treatments for Alzheimer's disease and related dementias.
Statistical methods to characterize patients who highly benefit across multifaceted clinical outcomes, from treatments in Alzheimers Disease and Related Dementias (ADRD)
This study is looking to find out which patients with Alzheimer's and related dementias are most likely to benefit from certain treatments, so we can help them get the best care possible while keeping any risks low.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11078273 on NIH RePORTER |
What this research studies
This research aims to develop statistical methods to identify patients who will experience significant benefits from treatments for Alzheimer's disease and related dementias across multiple clinical outcomes. By analyzing various patient characteristics, the study seeks to predict which individuals are likely to gain the most from specific therapies while minimizing potential harms. The approach involves constructing outcome predictions based on a wide range of patient data and synthesizing these predictions to create a profile of high-benefit patients. This innovative methodology addresses the current gap in accurately characterizing patients who can benefit from treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias who are seeking treatment options.
Not a fit: Patients with early-stage cognitive impairment or those not diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment options for patients with Alzheimer's disease, improving their quality of life.
How similar studies have performed: Previous research has shown promise in using statistical methods to improve patient outcomes in similar contexts, indicating a potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Frangakis, Constantine E — Johns Hopkins University
- Study coordinator: Frangakis, Constantine E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.