Identifying patients at risk for esophageal cancer through biomarker analysis
Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus
This study is looking for signs in tissue samples from people with Barrett's esophagus to help figure out who might be more likely to develop cancer, so that those at higher risk can get better screening and treatment.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10988229 on NIH RePORTER |
What this research studies
This research focuses on Barrett's esophagus, a condition that can lead to esophageal adenocarcinoma, which is a serious type of cancer. The study aims to identify specific biomarkers that can help determine which patients with Barrett's esophagus are at higher risk of developing cancer. By analyzing tissue samples from patients, researchers will develop and validate a biomarker panel that can effectively stratify risk. This approach could lead to better screening and treatment options for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Barrett's esophagus, particularly those with non-dysplastic Barrett's esophagus or low-grade dysplasia.
Not a fit: Patients without Barrett's esophagus or those with advanced esophageal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more personalized treatment for patients at risk of esophageal cancer.
How similar studies have performed: Previous research has shown promise in using biomarkers for cancer risk stratification, indicating that this approach may be effective.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Stachler, Matthew D — University of California, San Francisco
- Study coordinator: Stachler, Matthew D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.