Identifying pathways that lead to heart failure in older adults
Official title: Proteomic signatures to identify pathways underlying the progression to heart failure
Funded at Ut Southwestern Medical Center · NIH-10895160 · Data updated 2026-11-12
This study is looking at how inflammation and other biological factors affect heart failure in older adults, using blood samples to find new ways to treat and understand this condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 4, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $763,132 |
| NIH project number | 7R01HL148218-04 |
| Project ID | NIH-10895160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those at risk for or currently experiencing heart failure.
✕Less likely to help
Patients who are younger or do not have any cardiovascular issues may not benefit from this research.
What this research studies
This research investigates how inflammation and other biological pathways contribute to the development of heart failure, particularly in elderly patients. By analyzing blood samples to quantify thousands of proteins, the study aims to uncover new targets for treatment and better understand the progression of heart failure. Participants will be part of a large cohort study that combines detailed health assessments with advanced proteomic techniques to identify risk factors and potential therapies. The goal is to provide insights that could lead to more effective treatments for heart failure in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the underlying causes of heart failure in the elderly.
How similar studies have gone: Previous research has shown promise in using proteomic approaches to identify disease pathways, suggesting potential for success in this novel investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Shah, Amil M — Ut Southwestern Medical Center
- Study coordinator: Shah, Amil M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.