Identifying pathogens in endocarditis directly from blood samples
Official title: Direct-from-specimen identification of pathogens common in endocarditis
Funded at Helixbind, INC. · NIH-11013411 · Data updated 2026-11-12
This study is testing a new, quick test that can help doctors find infections in the heart faster and more accurately, so patients can get the right treatment sooner and spend less time in the hospital.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Helixbind, INC. NIH-funded |
| Lab location | 1 site (Boxborough, UNITED STATES) |
| Project start | January 4, 2018 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,049,999 |
| NIH project number | 5R44AI136064-06 |
| Project ID | NIH-11013411 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suspected of having infective endocarditis, particularly those experiencing symptoms of bloodstream infections.
✕Less likely to help
Patients who do not have infective endocarditis or those who are not experiencing symptoms of a bloodstream infection may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis of infective endocarditis, a serious condition caused by bacterial or fungal infections in the heart. It aims to develop a rapid, automated test called RaPID/IE that can identify these pathogens directly from blood samples in about three hours, eliminating the need for traditional culture methods that can take much longer and may yield false negatives. By providing faster and more accurate results, this approach seeks to enhance patient outcomes and reduce hospital stays.
Why it matters
Potential benefit: If successful, this research could lead to quicker and more accurate diagnoses of infective endocarditis, improving treatment outcomes for patients.
How similar studies have gone: Other research has shown promise in developing rapid diagnostic tests for infections, indicating that this approach could be effective.
Where this research is happening
-
Helixbind, INC.
Boxborough, United States Active
Researchers
- Principal investigator: Singer, Alon — Helixbind, INC.
- Study coordinator: Singer, Alon
Related research
Other NIH-funded projects on the same topics.
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Automated, culture-free test to detect bloodstream infections directly from blood
A new automated test called RaPID/BSI can identify bloodstream infections directly from a blood sample within four hours, helping doctors choose the right treatment sooner.
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Ultra-sensitive blood test to spot active Lyme disease infections
A new blood test called RaPID/LD aims to detect active Borrelia infections directly from blood, helping people with suspected Lyme disease get an early and accurate diagnosis.
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Automated test that quickly identifies bloodstream infections from a blood sample
A fast, blood-based test from HelixBind that can identify bloodstream infections within about 4 hours to guide the right treatment.
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Direct-from-specimen test for bloodstream infections
A fast, blood test developed by HelixBind to identify bloodstream infections directly from a blood sample in about 4 hours, helping doctors treat septicemia sooner.
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Direct-from-specimen test for fast endocarditis pathogens
A fast, automated blood test can identify bacteria or fungi causing endocarditis without culture, helping doctors choose the right treatment sooner.
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A faster way to detect bloodstream infections directly from blood
This project is creating a new device to quickly find out if you have a bloodstream infection, which can lead to a serious condition called sepsis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.