Identifying pathogens and their antibiotic resistance directly from blood samples
Changing Cultures in Sepsis: Rapid single-cell pathogen identification and antibiotic susceptibility testing directly from whole blood
This study is working on a new, quick way to find out what germs are causing sepsis directly from your blood, so doctors can diagnose and treat you faster and more accurately.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10850916 on NIH RePORTER |
What this research studies
This research focuses on improving the diagnosis and treatment of sepsis, a life-threatening condition often caused by bloodstream infections. It aims to develop a rapid, microfluidic system that can detect and identify pathogens directly from whole blood without the need for amplification. By using advanced techniques like multispectral barcoding and nanotube-assisted microwave electroporation, the study seeks to classify pathogens and assess their susceptibility to antibiotics at a single-cell level. This approach could significantly reduce the time it takes to diagnose infections and determine the appropriate treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients presenting with symptoms of sepsis or suspected bloodstream infections.
Not a fit: Patients with non-infectious causes of sepsis or those who do not have bloodstream infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnosis of sepsis, ultimately improving patient outcomes and reducing mortality rates.
How similar studies have performed: Other research has shown promise in rapid pathogen identification and antibiotic susceptibility testing, but this specific approach using microfluidics and single-cell analysis is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Yang, Samuel — Stanford University
- Study coordinator: Yang, Samuel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.