Identifying pain treatment responses in knee osteoarthritis
Official title: Brain-based and clinical phenotyping of pain pharmacotherapy in knee OA
Funded at Northwestern University at Chicago · NIH-10906980 · Data updated 2026-11-12
This study is looking at how well different treatments for knee osteoarthritis pain, like naproxen and duloxetine, work for people based on their individual characteristics, so we can find the best way to help each person feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $677,252 |
| NIH project number | 5R01AR081854-02 |
| Project ID | NIH-10906980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing moderate to severe pain from knee osteoarthritis.
✕Less likely to help
Patients with mild knee pain or those not diagnosed with osteoarthritis may not benefit from this research.
What this research studies
This research investigates how different treatments for knee osteoarthritis (OA) pain affect individuals based on their unique biological markers. Participants will be randomly assigned to receive either naproxen, duloxetine, or a placebo, and their responses will be monitored over a 6-week period. The study aims to collect various data, including patient demographics, clinical outcomes, and brain imaging, to better understand which treatments work best for specific patient profiles. By identifying these responder phenotypes, the research hopes to personalize pain management strategies for OA patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized pain management options for patients with knee osteoarthritis.
How similar studies have gone: Similar research has shown promise in personalizing pain treatment based on biomarkers, indicating a potential for success in this approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Schnitzer, Thomas Jack — Northwestern University at Chicago
- Study coordinator: Schnitzer, Thomas Jack
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.