Identifying new types of tau-related brain diseases.
Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10987055
This study is looking at a special type of tau protein that is connected to brain diseases, especially one called limbic-predominant neuronal inclusion body 4R tauopathy, to help us understand how these proteins clump together and affect brain function, which could lead to better ways to diagnose and treat patients with related conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10987055 on ClinicalTrials.gov |
What this research studies
This research investigates the structures of tau proteins that are linked to neurodegenerative diseases, particularly focusing on a novel form of tauopathy called limbic-predominant neuronal inclusion body 4R tauopathy. By analyzing tau filaments from patients with progressive supranuclear palsy, the research aims to understand how these proteins aggregate and contribute to brain dysfunction. Patients may benefit from insights into the mechanisms of their conditions, potentially leading to better diagnostic and therapeutic strategies. The study employs advanced imaging techniques to visualize tau structures at a molecular level.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with progressive supranuclear palsy or other tauopathies.
Not a fit: Patients with neurodegenerative diseases not related to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with tauopathies and related neurodegenerative diseases.
How similar studies have performed: Previous research has shown success in understanding tauopathies through structural analysis, indicating that this approach has potential for significant findings.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VIDAL, RUBEN — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: VIDAL, RUBEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease