Identifying new types of tau-related brain diseases.
Official title: Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.
Funded at Indiana University Indianapolis · NIH-10987055 · Data updated 2026-11-12
This study is looking at a special type of tau protein that is connected to brain diseases, especially one called limbic-predominant neuronal inclusion body 4R tauopathy, to help us understand how these proteins clump together and affect brain function, which could lead to better ways to diagnose and treat patients with related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $596,985 |
| NIH project number | 5R01AG080001-03 |
| Project ID | NIH-10987055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with progressive supranuclear palsy or other tauopathies.
✕Less likely to help
Patients with neurodegenerative diseases not related to tau pathology may not benefit from this research.
What this research studies
This research investigates the structures of tau proteins that are linked to neurodegenerative diseases, particularly focusing on a novel form of tauopathy called limbic-predominant neuronal inclusion body 4R tauopathy. By analyzing tau filaments from patients with progressive supranuclear palsy, the research aims to understand how these proteins aggregate and contribute to brain dysfunction. Patients may benefit from insights into the mechanisms of their conditions, potentially leading to better diagnostic and therapeutic strategies. The study employs advanced imaging techniques to visualize tau structures at a molecular level.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with tauopathies and related neurodegenerative diseases.
How similar studies have gone: Previous research has shown success in understanding tauopathies through structural analysis, indicating that this approach has potential for significant findings.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Vidal, Ruben — Indiana University Indianapolis
- Study coordinator: Vidal, Ruben
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.