Identifying new treatments for diseases caused by certain parasites
Development of a multiplexed assay in kinetoplastid parasites to identify probes for glycolysis
['FUNDING_R01'] · CLEMSON UNIVERSITY · NIH-10812462
This study is looking at how certain parasites, which can cause diseases, use sugar to live and grow, and it aims to find new medicines that can stop them by testing different compounds to see which ones can block their sugar use.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEMSON UNIVERSITY (nih funded) |
| Locations | 1 site (CLEMSON, UNITED STATES) |
| Trial ID | NIH-10812462 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain parasites, like Trypanosoma brucei and Leishmania spp., use glucose for their survival and development. By using live parasites that express special sensors, the researchers aim to measure how these parasites take up and metabolize glucose. They will develop a high-throughput screening assay to test a large collection of compounds to find those that can disrupt glucose metabolism in these parasites. This innovative approach could lead to the discovery of new antiparasitic drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by diseases caused by kinetoplastid parasites, such as African sleeping sickness or leishmaniasis.
Not a fit: Patients with diseases not caused by kinetoplastid parasites may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for diseases caused by kinetoplastid parasites, improving patient outcomes.
How similar studies have performed: Other research has shown promise in targeting glucose metabolism in parasites, suggesting that this approach could be effective.
Where this research is happening
CLEMSON, UNITED STATES
- CLEMSON UNIVERSITY — CLEMSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORRIS, JAMES CULVIN — CLEMSON UNIVERSITY
- Study coordinator: MORRIS, JAMES CULVIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.