Identifying new targets for treating frontotemporal dementia.
Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
This study is looking into how a specific brain problem related to dementia affects people, and it aims to understand the early signs of the condition so that researchers can find new ways to help those who are affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10915040 on NIH RePORTER |
What this research studies
This research aims to uncover the mechanisms behind frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), a condition linked to dementia. A diverse team of experts in genetics, neuroscience, and pathology is collaborating to explore how TDP-43 dysfunction leads to mis-splicing events, which may be early indicators of the disease. The project will generate high-resolution data on TDP-43 activity in human brains, making this information accessible to the broader research community to foster new hypotheses and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with frontotemporal dementia or those showing early signs of cognitive decline related to TDP-43 pathology.
Not a fit: Patients with other forms of dementia not associated with TDP-43 dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of sensitive biomarkers and therapeutic targets for frontotemporal dementia.
How similar studies have performed: Previous research has shown promise in exploring TDP-43's role in neurodegenerative diseases, suggesting that this approach could yield significant insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Gitler, Aaron D. — Stanford University
- Study coordinator: Gitler, Aaron D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.