Identifying new small molecules for targeted cancer therapy
Official title: A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy
Funded at University of Tx Md Anderson Can Ctr · NIH-11258638 · Data updated 2026-11-12
This study is looking for new tiny molecules that can help break down certain proteins that cause cancer, especially in patients with acute myeloid leukemia and multiple myeloma, with the hope of finding better treatments that work even when other therapies fail.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $224,100 |
| NIH project number | 4R00CA287069-02 |
| Project ID | NIH-11258638 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients diagnosed with acute myeloid leukemia or multiple myeloma who have not responded to standard treatments.
✕Less likely to help
Patients with cancers that are not related to acute myeloid leukemia or multiple myeloma may not benefit from this research.
What this research studies
This research focuses on developing a novel method to identify small molecules, known as molecular glues, that can help target and degrade specific proteins involved in cancer. By using a chemoproteomic approach, the researchers aim to systematically discover these compounds, which have been difficult to find using traditional methods. The study will explore how these molecular glues can be used to overcome resistance in cancer treatments, particularly in acute myeloid leukemia and multiple myeloma. Patients may benefit from new therapies that more effectively target their cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective targeted therapies for patients with difficult-to-treat cancers.
How similar studies have gone: Previous research has shown promise in using molecular glues for targeted cancer therapy, indicating potential for success in this novel approach.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Yoon, Hojong — University of Tx Md Anderson Can Ctr
- Study coordinator: Yoon, Hojong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.