Identifying new markers for colorectal cancer outcomes in diverse populations
Official title: Project 2: Discovery and validation of novel molecular and immune predictors of colorectal cancer mortality and response to treatment in racially and ethnically diverse patient populations
Funded at Fred Hutchinson Cancer Center · NIH-10935389 · Data updated 2026-11-12
This study is looking at how colorectal cancer affects different racial and ethnic groups, especially African Americans and Alaska Natives, to find new ways to predict how well patients will respond to treatment and how long they might live, using advanced techniques to analyze tumor samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $286,521 |
| NIH project number | 1P50CA285275-01A1 |
| Project ID | NIH-10935389 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American, Alaska Native, Hispanic, and non-Hispanic White patients diagnosed with colorectal cancer.
✕Less likely to help
Patients with colorectal cancer who do not belong to the targeted racial and ethnic groups may not receive direct benefits from this research.
What this research studies
This research investigates the differences in colorectal cancer (CRC) outcomes among racially and ethnically diverse groups, particularly focusing on African American and Alaska Native populations. By utilizing advanced tumor molecular profiling techniques, the study aims to discover new biomarkers that can predict patient responses to treatments and overall survival rates. The research will analyze tumor samples from a large cohort of CRC patients to identify spatially resolved predictors of treatment response and mortality. This approach seeks to enhance understanding of how genetic and environmental factors contribute to cancer disparities.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for colorectal cancer, improving survival rates and quality of life for patients in diverse populations.
How similar studies have gone: Previous research has shown success in using molecular profiling to improve cancer treatment outcomes, but this specific approach focusing on diverse populations is relatively novel.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Li, Christopher I — Fred Hutchinson Cancer Center
- Study coordinator: Li, Christopher I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.