Identifying new markers for aging cells
Single-cell proteomic identification of novel markers of senescence
This study is looking at how certain cells in our body stop dividing as we get older and can cause health issues, and it's for anyone interested in understanding aging better; the researchers want to find specific markers to identify these cells, which could help improve how we diagnose and treat age-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10928812 on NIH RePORTER |
What this research studies
This research focuses on understanding cellular senescence, a state where cells stop dividing and can contribute to inflammation and disease as we age. By using advanced single-cell proteomic technology, the researchers aim to identify specific markers that can distinguish senescent cells from other cell types in human tissues. This approach will help map these cells in a three-dimensional context, providing insights into their role in aging and disease progression. The findings could lead to better diagnostic tools and therapeutic strategies for age-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or diseases associated with cellular senescence.
Not a fit: Patients who are not experiencing age-related conditions or do not have a significant accumulation of senescent cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of age-related diseases by targeting senescent cells.
How similar studies have performed: Previous research has shown promise in identifying cellular markers for various conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dou, Zhixun — Massachusetts General Hospital
- Study coordinator: Dou, Zhixun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.