Identifying new genes linked to normal-tension glaucoma
Official title: Validating novel candidate genes for normal-tension glaucoma
Funded at University of Michigan at Ann Arbor · NIH-10934336 · Data updated 2026-11-12
This study is looking at how our genes might play a role in normal-tension glaucoma, a type of eye condition that damages the optic nerve even when eye pressure is normal, and it’s aimed at families who have a history of this condition to help find better treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $42,099 |
| NIH project number | 5F31EY035557-02 |
| Project ID | NIH-10934336 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with a family history of normal-tension glaucoma or those diagnosed with the condition.
✕Less likely to help
Patients with other forms of glaucoma that are not related to genetic factors may not benefit from this research.
What this research studies
This research focuses on discovering genetic factors that contribute to normal-tension glaucoma (NTG), a condition where optic nerve damage occurs despite normal eye pressure. By studying families with a history of NTG, the researchers aim to identify specific gene variants that may increase the risk of developing this condition. The approach includes advanced genetic analyses such as whole-exome and whole-genome sequencing to pinpoint these candidate genes. Understanding these genetic mechanisms could lead to better-targeted therapies for patients suffering from NTG.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and personalized therapies for patients with normal-tension glaucoma.
How similar studies have gone: Previous research has successfully identified genetic factors in other types of glaucoma, suggesting that this approach may yield valuable insights for normal-tension glaucoma as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Presley, William Thomas — University of Michigan at Ann Arbor
- Study coordinator: Presley, William Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.