Identifying new genes linked to normal-tension glaucoma
Validating novel candidate genes for normal-tension glaucoma
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10934336
This study is looking at how our genes might play a role in normal-tension glaucoma, a type of eye condition that damages the optic nerve even when eye pressure is normal, and it’s aimed at families who have a history of this condition to help find better treatments.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10934336 on ClinicalTrials.gov |
What this research studies
This research focuses on discovering genetic factors that contribute to normal-tension glaucoma (NTG), a condition where optic nerve damage occurs despite normal eye pressure. By studying families with a history of NTG, the researchers aim to identify specific gene variants that may increase the risk of developing this condition. The approach includes advanced genetic analyses such as whole-exome and whole-genome sequencing to pinpoint these candidate genes. Understanding these genetic mechanisms could lead to better-targeted therapies for patients suffering from NTG.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with a family history of normal-tension glaucoma or those diagnosed with the condition.
Not a fit: Patients with other forms of glaucoma that are not related to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and personalized therapies for patients with normal-tension glaucoma.
How similar studies have performed: Previous research has successfully identified genetic factors in other types of glaucoma, suggesting that this approach may yield valuable insights for normal-tension glaucoma as well.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRESLEY, WILLIAM THOMAS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: PRESLEY, WILLIAM THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.