Identifying new coding regions in the human genome
Expanding the known coding genome: identifying biological function for novel tORFs
This study is looking at parts of our DNA that might help make proteins, which could be important for understanding how our bodies work and how genetic disorders happen, using data from specific human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10991812 on NIH RePORTER |
What this research studies
This research investigates previously overlooked regions of the human genome that may code for proteins, known as translated open reading frames (tORFs). By utilizing advanced computational methods and functional genomics datasets, the researchers aim to systematically identify and characterize these novel tORFs, which could play significant roles in biological processes. The study focuses on analyzing data from human lymphoblastoid cell lines to uncover these hidden genomic features and their potential functions. This approach could enhance our understanding of genetic disorders and biological mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or those interested in the genetic basis of diseases.
Not a fit: Patients with well-characterized genetic conditions that are fully understood and do not involve novel coding regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic disorders and the biological functions of previously unrecognized proteins.
How similar studies have performed: Other research has successfully identified novel coding regions using similar genomic approaches, indicating the potential for meaningful discoveries in this area.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Sidney — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Wang, Sidney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.