Identifying new blood markers for cognitive aging and Alzheimer's disease
Official title: Utilizing Plasma Proteomics to Identify Novel Biomarkers of Cognitive Aging
Funded at Vanderbilt University · NIH-10995274 · Data updated 2026-11-12
This study is looking at blood samples from older adults to find new proteins that might help predict cognitive decline and Alzheimer's disease, with the hope of improving our understanding of these conditions and finding better treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $34,296 |
| NIH project number | 5F30AG085905-02 |
| Project ID | NIH-10995274 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are adults aged 65 and older, particularly those showing early signs of cognitive decline or with vascular risk factors.
✕Less likely to help
Patients under the age of 65 or those without any cognitive impairment or vascular risk factors may not benefit from this research.
What this research studies
This research investigates the role of plasma proteomics in identifying novel biomarkers that could predict cognitive aging and Alzheimer's disease. By analyzing blood samples from older adults, the study aims to uncover specific proteins associated with cognitive decline, particularly focusing on the interplay between Alzheimer's pathology and vascular dysfunction. The goal is to develop a better understanding of how these factors contribute to cognitive impairment and to identify potential new targets for treatment. Patients may be involved in providing blood samples and participating in assessments of cognitive function over time.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective interventions for cognitive decline in older adults.
How similar studies have gone: Previous research has shown promise in using proteomics to identify biomarkers for various diseases, suggesting that this approach could yield valuable insights for cognitive aging as well.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Adegboye, Hailey — Vanderbilt University
- Study coordinator: Adegboye, Hailey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.