Identifying new biomarkers for tumor burden in neurofibromatosis type 1
Developing Novel Biomarkers of Plexiform Neurofibroma Tumor Burden
['FUNDING_OTHER'] · LURIE CHILDREN'S HOSPITAL OF CHICAGO · NIH-11142173
This study is looking for new ways to track tumor growth in children with neurofibromatosis type 1 (NF1) by testing blood samples, which could make it easier and less invasive to monitor their condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LURIE CHILDREN'S HOSPITAL OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11142173 on ClinicalTrials.gov |
What this research studies
This research focuses on neurofibromatosis type 1 (NF1), a genetic disorder that often leads to the development of plexiform neurofibromas (PNFs) in children. The study aims to discover new biomarkers that can indicate tumor burden, which is currently challenging due to the limitations of MRI imaging. By analyzing plasma samples from both animal models and NF1 patients, researchers will utilize advanced techniques like mass spectrometry to identify specific biomarker signals associated with tumor growth. This approach could provide a less invasive and more accessible method for monitoring tumor burden in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neurofibromatosis type 1 who are experiencing plexiform neurofibromas.
Not a fit: Patients without neurofibromatosis type 1 or those who do not have plexiform neurofibromas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and management of tumor burden in children with neurofibromatosis type 1.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for other tumor types, suggesting potential success for this novel approach in NF1.
Where this research is happening
CHICAGO, UNITED STATES
- LURIE CHILDREN'S HOSPITAL OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PRADA, CARLOS ENRIQUE — LURIE CHILDREN'S HOSPITAL OF CHICAGO
- Study coordinator: PRADA, CARLOS ENRIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.