Identifying new biomarkers for gastric cancer risk using blood metabolites
Official title: Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
Funded at Sloan-Kettering Inst Can Research · NIH-10883354 · Data updated 2026-11-12
This study is looking at how certain substances in the blood might help predict the risk of developing gastric cancer in people who have a Helicobacter pylori infection, and it aims to find easy ways to spot this risk without needing invasive tests.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $764,565 |
| NIH project number | 1R37CA283041-01A1 |
| Project ID | NIH-10883354 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are infected with Helicobacter pylori and are at risk for developing gastric cancer.
✕Less likely to help
Patients who do not have Helicobacter pylori infection or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the role of circulating metabolites as potential risk biomarkers for gastric cancer, particularly in individuals infected with Helicobacter pylori. By utilizing advanced metabolomics techniques, the study aims to identify non-invasive biomarkers that can help assess the risk of developing gastric cancer in high-risk populations. The research will involve a large multi-center prospective cohort, allowing for a comprehensive analysis of how various metabolites relate to gastric cancer risk. Patients will be monitored over time to gather data on their metabolite levels and cancer development.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for gastric cancer, potentially saving lives through early detection.
How similar studies have gone: Previous studies have successfully identified risk biomarkers for other cancers using metabolomics, suggesting a promising avenue for gastric cancer as well.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Shu, Xiang — Sloan-Kettering Inst Can Research
- Study coordinator: Shu, Xiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.