Identifying nerve cells that connect the liver to the brain
Functional identification of vagal sensory neurons innervating the liver
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-10911227
This study is looking at how certain nerve cells help send messages from the liver to the brain, which might affect feelings and eating habits, especially for people dealing with depression or bipolar disorder.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-10911227 on ClinicalTrials.gov |
What this research studies
This research investigates how specific nerve cells, known as vagal sensory neurons, communicate signals from the liver to the brain, which may influence emotions and behaviors, particularly in individuals with psychological disorders. By analyzing the neural pathways and their physiological responses, the study aims to understand how these signals affect appetite and mood in patients with conditions like depression and bipolar disorder. The approach combines advanced tracing techniques with behavioral assessments to explore the role of these neurons in regulating eating behaviors and emotional responses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with psychological disorders such as depression or bipolar disorder who experience changes in appetite.
Not a fit: Patients without psychological disorders or those not experiencing appetite changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for psychological disorders by targeting the neural pathways that influence appetite and mood.
How similar studies have performed: While the specific focus on vagal sensory neurons and their role in appetite regulation is relatively novel, similar research has shown promising results in understanding the gut-brain connection in various psychological conditions.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JO, YOUNG-HWAN — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: JO, YOUNG-HWAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.