Identifying molecular types of Alzheimer's disease linked to cognitive function
Official title: Identification and characterization of molecular subtypes of Alzheimer's disease associated with cognitive function through cross-omics data integration
Funded at Washington University · NIH-11117069 · Data updated 2026-11-12
This study is looking at different types of Alzheimer's disease to see how they affect thinking skills in older adults, with the hope of finding new ways to diagnose and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $148,581 |
| NIH project number | 5K25AG083057-03 |
| Project ID | NIH-11117069 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding different molecular subtypes of Alzheimer's disease (AD) and how they relate to cognitive function in older adults. The project involves integrating various biological data types, known as cross-omics, to identify specific biomarkers that could help in diagnosing and treating AD. The principal investigator, Dr. Eteleeb, will receive training in neurology and genetics to enhance his ability to conduct this important research. The ultimate goal is to improve our understanding of AD and develop targeted interventions for patients.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment options for patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in identifying molecular subtypes of Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Eteleeb, Abdallah M — Washington University
- Study coordinator: Eteleeb, Abdallah M
Related research
Other NIH-funded projects on the same topics.
-
Understanding how daily activity patterns affect memory and dementia risk
This project looks at how a full day of activities – including sleep, light and moderate exercise, and sitting time – might influence thinking skills and the chance of developing Alzheimer’s disease or related dementias.
-
Aging fat cells and their impact on memory and Alzheimer's disease
Researchers are looking at whether aged, harmful cells in body fat send signals that damage the brain and speed memory loss in people at risk for Alzheimer's.
-
SARS-CoV-2, APOE, and dementia: how COVID-19 affects thinking in aging and Alzheimer’s
This NIH grant explores how COVID-19 may impact brain function and pathology in people with aging or Alzheimer's disease, including how APOE genes might influence the effects.
-
Understanding how sleep problems in older couples relate to thinking skills and Alzheimer's risk
This project looks at how insomnia in older couples may influence memory and thinking over time, with the goal of better understanding Alzheimer’s disease progression.
-
Hippocampal neurogenesis and its link to memory in Alzheimer’s disease
This study investigates whether new brain cells form in the hippocampus of people with Alzheimer’s and how this may relate to memory and cognitive decline.
-
How air quality and neighborhood design affect thinking and social connection in rural older adults
This project uses wearables and daily surveys to look at whether air pollution, local neighborhood features, and social isolation affect thinking and memory in middle-aged and older rural adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.