Identifying molecular drivers of neuropsychiatric symptoms in Alzheimer's dementia
The brain multi-omic approach to identify key molecular drivers of neuropsychiatric symptoms in Alzheimer's dementia
This study is looking at how genes might play a role in causing symptoms like depression, anxiety, and sleep problems in people with mild cognitive impairment and Alzheimer's disease, with the hope of finding new ways to help treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11140368 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms behind neuropsychiatric symptoms (NPS) in individuals with mild cognitive impairment and Alzheimer's disease. By analyzing data from approximately 32,000 participants, the study aims to identify novel genes associated with these debilitating symptoms, which include depression, anxiety, and sleep disturbances. The approach combines genome-wide association studies with brain transcriptomic and proteomic profiles to pinpoint potential therapeutic targets. This could lead to safer and more effective treatments for patients suffering from NPS.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with mild cognitive impairment, Alzheimer's disease, or related dementias who experience neuropsychiatric symptoms.
Not a fit: Patients without a diagnosis of mild cognitive impairment or Alzheimer's disease, or those not experiencing neuropsychiatric symptoms, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that alleviate neuropsychiatric symptoms in Alzheimer's patients, improving their quality of life.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to neuropsychiatric symptoms, suggesting that this approach could yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Wingo, Aliza Pham — University of California at Davis
- Study coordinator: Wingo, Aliza Pham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.