Identifying molecular changes in Lewy body dementia
Utilization of proteomics and lipidomics to identify modifiers of LBD
['FUNDING_OTHER'] · MAYO CLINIC JACKSONVILLE · NIH-10686900
This study is looking at the brain chemistry of people with Lewy body dementia to find out what goes wrong at a molecular level, which could help us create better ways to diagnose and treat the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10686900 on ClinicalTrials.gov |
What this research studies
This research aims to uncover the molecular networks involved in Lewy body dementia (LBD) by using advanced techniques in proteomics and lipidomics. By analyzing brain specimens from individuals with LBD and comparing them to healthy controls, the study seeks to identify key molecules that contribute to the disease's progression. The approach involves cutting-edge mass spectrometry to characterize proteins and lipids, which may help in understanding the interactions between amyloid-beta and alpha-synuclein. This research is crucial for developing better diagnostic and therapeutic strategies for LBD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body dementia or those exhibiting symptoms of the disease.
Not a fit: Patients with other forms of dementia, such as frontotemporal dementia or vascular dementia, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting, diagnosing, and treating Lewy body dementia.
How similar studies have performed: Previous research has shown promise in using proteomics and lipidomics to understand neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PENG, JUNMIN — MAYO CLINIC JACKSONVILLE
- Study coordinator: PENG, JUNMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease