Identifying mimics of chemical allergens that cause asthma
Official title: Discovering epitope mimics (mimitopes) of chemical allergens that cause occupational asthma
Funded at Yale University · NIH-10914629 · Data updated 2026-11-12
This study is looking for tiny molecules that act like the chemicals causing asthma and allergies at work, hoping to find better ways to diagnose and treat people who suffer from these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $167,336 |
| NIH project number | 5R21OH012524-02 |
| Project ID | NIH-10914629 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced occupational exposure to chemical allergens and suffer from asthma or other related allergic conditions.
✕Less likely to help
Patients who do not have a history of chemical exposure or those with non-occupational asthma may not benefit from this research.
What this research studies
This research aims to uncover small molecules that mimic the structure of chemical allergens responsible for occupational asthma and other related conditions. By utilizing advanced technology and unique laboratory-generated reagents, the project seeks to identify these mimics, known as mimitopes. The findings could lead to improved diagnostics and potential therapies for individuals affected by chemically-induced allergies. The study focuses on understanding how these allergens interact with the immune system, which has been a challenging area in allergy research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for patients suffering from occupational asthma and related conditions.
How similar studies have gone: While the approach of identifying mimotopes is innovative, similar research has shown promise in understanding allergen interactions with the immune system.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Wisnewski, Adam — Yale University
- Study coordinator: Wisnewski, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.