Identifying microRNA markers for heart transplant rejection and complications
MicroRNA Biomarkers of Allograft Rejection and Cardiac Allograft Vasculopathy in Cardiac Transplantation
['FUNDING_OTHER'] · INOVA HEALTH CARE SERVICES · NIH-10869894
This study is looking at tiny molecules in your blood that could help doctors spot heart transplant issues early, making it easier to keep you healthy after your surgery.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INOVA HEALTH CARE SERVICES (nih funded) |
| Locations | 1 site (Fairfax, UNITED STATES) |
| Trial ID | NIH-10869894 on ClinicalTrials.gov |
What this research studies
This research focuses on exploring circulating, cell-free microRNAs (ccf-miRs) as potential non-invasive biomarkers for detecting allograft rejection and cardiac allograft vasculopathy (CAV) in heart transplant patients. The approach involves isolating these microRNAs from blood samples and using advanced genomic sequencing techniques to analyze them. By combining transcriptomic data with clinical information, the research aims to develop a clinical panel of biomarkers that can help in the early detection of transplant complications, ultimately improving patient management and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone heart transplantation and are at risk for allograft rejection or cardiac allograft vasculopathy.
Not a fit: Patients who have not received a heart transplant or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of heart transplant rejection, potentially saving lives and improving the quality of care for transplant recipients.
How similar studies have performed: Previous research has shown promise in using biomarkers for transplant rejection, indicating that this approach could be a meaningful advancement in the field.
Where this research is happening
Fairfax, UNITED STATES
- INOVA HEALTH CARE SERVICES — Fairfax, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHAH, PALAK — INOVA HEALTH CARE SERVICES
- Study coordinator: SHAH, PALAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.