Identifying metabolic changes to improve Alzheimer's disease treatment
Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD
This study is looking at how Alzheimer's disease affects the body's metabolism to find new ways to treat and prevent it, and it hopes to help patients by speeding up the discovery of better therapies.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10475301 on NIH RePORTER |
What this research studies
This research focuses on understanding the metabolic changes associated with Alzheimer's disease (AD) to identify new drug targets for treatment and prevention. By analyzing large-scale molecular data from human brain samples, the project aims to uncover the biochemical pathways involved in AD, particularly those related to lipid processing and immune function. The approach combines metabolomics with network modeling to provide insights into the disease's heterogeneity, which is crucial for developing precision medicine strategies. Patients may benefit from this research as it seeks to accelerate the discovery of effective therapies for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for Alzheimer's disease or those in the early stages of the condition.
Not a fit: Patients with advanced Alzheimer's disease or those not exhibiting any symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for Alzheimer's disease.
How similar studies have performed: Previous research in metabolomics has shown promise in identifying biomarkers and drug targets for various diseases, suggesting a potential for success in this novel application for Alzheimer's disease.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — Duke University
- Study coordinator: Kaddurah-Daouk, Rima F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.