Identifying medications that may cause pancreatic injury
Official title: Determining medications associated with drug-induced pancreatic injury through novel pharmacoepidemiology techniques that assess causation
Funded at University of Pittsburgh at Pittsburgh · NIH-11088122 · Data updated 2026-11-12
This study is looking into whether some medications might cause acute pancreatitis, a condition that can lead to serious hospital visits, and it's designed for anyone who wants to understand how their medications could affect their pancreas and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $388,425 |
| NIH project number | 5R01DK135876-03 |
| Project ID | NIH-11088122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced acute pancreatitis or are at risk for the condition due to medication use.
✕Less likely to help
Patients who have not experienced acute pancreatitis or are not taking medications that could potentially cause this condition may not benefit from this research.
What this research studies
This research investigates the potential link between certain medications and acute pancreatitis, a condition that leads to significant hospitalizations. By utilizing advanced pharmacoepidemiology techniques and electronic health databases, the study aims to identify which medications may contribute to drug-induced pancreatic injury (DIPI). This approach allows for a comprehensive analysis of medication effects while considering various patient factors, ultimately aiming to improve patient safety and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could help identify safe medications for patients at risk of acute pancreatitis, reducing hospitalizations and improving quality of life.
How similar studies have gone: Previous research has shown success in identifying medication-related adverse effects using similar pharmacoepidemiological approaches, indicating the potential for meaningful findings in this study.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Vajravelu, Ravy Kuppalapalle — University of Pittsburgh at Pittsburgh
- Study coordinator: Vajravelu, Ravy Kuppalapalle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.