Identifying markers that predict nasal polyp recurrence in patients with aspirin-related respiratory issues
Official title: Biomarkers predicting nasal polyp recurrence in aspirin-exacerbated respiratory disease
Funded at Brigham and Women's Hospital · NIH-11056424 · Data updated 2026-11-12
This study is looking at how certain biological markers in your body can help predict if nasal polyps will come back after surgery and aspirin treatment for those with aspirin-exacerbated respiratory disease (AERD), so that doctors can better tailor treatments for you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 2, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $260,445 |
| NIH project number | 1R21AI182809-01A1 |
| Project ID | NIH-11056424 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have AERD and have experienced nasal polyp recurrence after sinus surgery and aspirin therapy.
✕Less likely to help
Patients who do not have aspirin-exacerbated respiratory disease or those who have not undergone sinus surgery may not benefit from this research.
What this research studies
This research investigates the biological markers that may indicate the likelihood of nasal polyp recurrence in individuals suffering from aspirin-exacerbated respiratory disease (AERD) after they have undergone endoscopic sinus surgery and aspirin desensitization. The study will analyze both tissue samples and nasal fluid to identify specific proteins associated with inflammation and polyp regrowth. By employing advanced techniques such as proteomic and lipidomic analysis, the researchers aim to understand the complex interactions between different inflammatory pathways that contribute to this condition. The ultimate goal is to develop a reliable method for predicting which patients are at higher risk for recurrence, thereby improving treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for patients with AERD, potentially reducing the recurrence of nasal polyps and improving quality of life.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for other inflammatory conditions, suggesting that this approach may yield valuable insights, although the specific focus on AERD is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Buchheit, Kathleen Mary — Brigham and Women's Hospital
- Study coordinator: Buchheit, Kathleen Mary
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.