Identifying markers that predict breast cancer spread and treatment response
TMEM, MENAcalc, and MENAINV as Prognostic and Predictive Markers for Breast Cancer Metastasis
This study is looking at how certain conditions around breast cancer cells can help predict if the cancer will spread and how well treatments might work, specifically for patients with a type of breast cancer called ER+/HER2-, to find better ways to guide their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10880280 on NIH RePORTER |
What this research studies
This research investigates the role of specific cellular environments in breast cancer that may indicate the likelihood of metastasis and response to therapy. By using advanced imaging techniques, the study aims to identify a unique microenvironment involving tumor cells, macrophages, and endothelial cells that facilitates cancer cell entry into the bloodstream. The researchers will analyze human breast cancer samples to determine how these markers correlate with patient outcomes, particularly in those with ER+/HER2- breast cancer. The goal is to improve prognostic criteria and treatment strategies for patients at risk of metastatic disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ER+/HER2- breast cancer who are at risk of metastasis.
Not a fit: Patients with non-breast cancer conditions or those with different breast cancer subtypes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate predictions of breast cancer metastasis and tailored treatment options for patients.
How similar studies have performed: Previous research has shown promise in identifying prognostic markers for breast cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Rohan, Thomas E — Albert Einstein College of Medicine
- Study coordinator: Rohan, Thomas E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.