Identifying markers for reactivation of latent tuberculosis in HIV co-infected patients
Single cell trancriptomics to identify LTBI reactivation markers in TB/HIV co-infection
This study is looking at how latent tuberculosis can come back in people who also have HIV, and it hopes to find clues that could help doctors better monitor and treat those at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Biomedical Research Institute NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10685926 on NIH RePORTER |
What this research studies
This research investigates how latent tuberculosis infection (LTBI) can reactivate in individuals co-infected with HIV. By examining immune responses at the single-cell level, the study aims to identify specific biomarkers that indicate the risk of LTBI reactivation. The research utilizes a preclinical model involving rhesus macaques to understand the effects of antiretroviral therapy on immune activation and its relationship with LTBI. Patients may benefit from insights that could lead to improved monitoring and treatment strategies for those at risk of reactivation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are co-infected with HIV and have a history of latent tuberculosis infection.
Not a fit: Patients who are not co-infected with HIV or do not have latent tuberculosis infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better predictive markers for LTBI reactivation, allowing for timely interventions in HIV co-infected patients.
How similar studies have performed: Previous research has shown success in identifying immune markers in similar co-infection studies, suggesting potential for impactful findings in this area.
Where this research is happening
San Antonio, United States
- Texas Biomedical Research Institute — San Antonio, United States (Active)
Researchers
- Principal investigator: Sharan, Riti — Texas Biomedical Research Institute
- Study coordinator: Sharan, Riti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.