Identifying markers for early detection of pancreatic cancer
Official title: Deiminated molecules as markers for developing pancreatic cancer - A1
Funded at Mayo Clinic Jacksonville · NIH-11001477 · Data updated 2026-11-12
This study is looking for specific signs in blood and tissue samples that could help doctors find pancreatic cancer earlier, focusing on a protein called PADI1, so that patients can get treatment sooner and improve their chances of recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $219,491 |
| NIH project number | 5R21CA279916-02 |
| Project ID | NIH-11001477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with high-grade pancreatic lesions or those at high risk for developing pancreatic cancer.
✕Less likely to help
Patients with advanced pancreatic cancer or those without any pancreatic lesions may not benefit from this research.
What this research studies
This research aims to discover specific markers that can help in the early detection of pancreatic ductal adenocarcinoma (PDA), a type of pancreatic cancer with a poor prognosis. The researchers will focus on a protein called PADI1 and its modified forms, which may be present in pancreatic tissue and blood samples. By analyzing these markers, the goal is to differentiate between non-cancerous and cancerous lesions, allowing for earlier and potentially life-saving interventions. The study will involve testing these markers in biopsy samples and liquid biopsies, which are less invasive than traditional methods.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of pancreatic cancer, significantly improving patient outcomes.
How similar studies have gone: Previous research has shown promise in identifying biomarkers for various cancers, suggesting that this approach could be effective for pancreatic cancer as well.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Storz, Peter — Mayo Clinic Jacksonville
- Study coordinator: Storz, Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.