Identifying leukemia-related genetic changes in newborns' cord blood
Backtracking Leukemia-Typical Somatic Alterations in Cord Blood at Single-cell Resolution
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-10894748
This study is looking at the genetic changes in newborns' cord blood to find out if there are early signs of leukemia, helping us understand which babies might be at a higher risk for developing this condition as they grow up.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10894748 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic changes associated with acute leukemia in newborns by analyzing their cord blood. The study aims to identify preleukemic clones that may lead to leukemia, focusing on children under 15 years old. By collecting and analyzing samples from approximately 250 childhood leukemia patients, researchers will use advanced techniques to detect specific genetic mutations and their frequency in the blood cells of newborns. This could help in understanding which infants are at higher risk for developing leukemia later in life.
Who could benefit from this research
Good fit: Ideal candidates for this research include newborns and infants, particularly those with a family history of leukemia or other risk factors.
Not a fit: Patients who are older than 15 years or those without any family history of leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification of infants at risk for leukemia, allowing for preventive measures and improved outcomes.
How similar studies have performed: Previous research has shown promise in identifying genetic markers for leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPECTOR, LOGAN G. — UNIVERSITY OF MINNESOTA
- Study coordinator: SPECTOR, LOGAN G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.