Identifying kidney function markers to assess risk of high potassium levels
Official title: Biomarkers of Kidney Secretory Function for Discriminating Risk of Hyperkalemia
Funded at Veterans Medical Research Fdn/san Diego · NIH-10907808 · Data updated 2026-11-12
This study is looking at how certain markers in the body can help find out which patients with heart failure and chronic kidney disease are at risk for high potassium levels, especially those taking medications like spironolactone, so that doctors can better manage their care.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Medical Research Fdn/san Diego NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $109,613 |
| NIH project number | 5R21HL169633-02 |
| Project ID | NIH-10907808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart failure or chronic kidney disease, especially those prescribed spironolactone.
✕Less likely to help
Patients without heart failure or chronic kidney disease, or those not taking medications that affect potassium levels, may not benefit from this research.
What this research studies
This research investigates how specific biomarkers related to kidney function can help identify patients at risk for hyperkalemia, a dangerous condition characterized by high potassium levels in the blood. The study focuses on individuals with heart failure and chronic kidney disease, particularly those taking medications like spironolactone. By analyzing kidney tubule secretion biomarkers, the researchers aim to improve risk assessment methods beyond current practices, which mainly consider glomerular filtration. The findings could lead to better management strategies for patients susceptible to hyperkalemia.
Why it matters
Potential benefit: If successful, this research could lead to more accurate identification of patients at risk for hyperkalemia, allowing for timely interventions and improved patient safety.
How similar studies have gone: Previous research has shown promise in using kidney secretion biomarkers to assess risks related to hyperkalemia, indicating that this approach may be effective.
Where this research is happening
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Veterans Medical Research Fdn/san Diego
San Diego, United States Active
Researchers
- Principal investigator: Wettersten, Nicholas — Veterans Medical Research Fdn/san Diego
- Study coordinator: Wettersten, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.