Identifying key proteins in cancer that can be targeted with drugs
Discovering and Characterizing Druggable Cysteines in Cancer Dependency Proteins
['FUNDING_CAREER'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11064864
This study is looking at special proteins in cancer cells that could be targeted by new treatments, and it aims to see how blocking one of these proteins, called TOE1, might help improve cancer care for patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11064864 on ClinicalTrials.gov |
What this research studies
This research focuses on discovering and characterizing specific proteins in cancer cells that have unique sites, known as cysteines, which can be targeted by new drugs. By using advanced techniques like Activity-Based Protein Profiling (ABPP) and base editing, the researchers aim to understand how these cysteines function and their role in cancer cell growth. The study will investigate the effects of inhibiting these proteins, particularly one called TOE1, to determine how it impacts cancer treatment. Patients may benefit from the development of new therapies that specifically target these proteins.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who may benefit from targeted therapies.
Not a fit: Patients with cancers that do not involve the specific proteins being studied may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new, more effective cancer therapies that specifically target vulnerable proteins in cancer cells.
How similar studies have performed: Other research has shown promise in targeting similar proteins in cancer, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, HAOXIN — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: LI, HAOXIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research, anti-cancer therapy, Cancer Biology