Identifying key markers in cancer cells that can resist treatment
Identification of essential biomarkers in the polyploid cancer cell lifecycle
This study is looking at why some ovarian cancer cells can keep growing even after chemotherapy, and it aims to find key genes that help these tough cells survive, so we can improve treatments for patients like you.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10949494 on NIH RePORTER |
What this research studies
This research investigates how certain cancer cells, specifically in high-grade serous ovarian carcinoma, can survive and thrive despite chemotherapy. It focuses on the process of whole-genome duplication, which leads to the formation of polyploid cancer cells that can evade the normal aging process of cells. By using advanced techniques like CRISPR-Cas9, the study aims to identify essential genes that contribute to the survival and proliferation of these resistant cancer cells. The ultimate goal is to connect laboratory findings with clinical observations to improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with high-grade serous ovarian carcinoma who are undergoing or have undergone chemotherapy.
Not a fit: Patients with other types of cancer or those who do not have high-grade serous ovarian carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with high-grade serous ovarian carcinoma, potentially improving survival rates.
How similar studies have performed: Other research has shown promising results in understanding the role of polyploidy in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Voelkel-Johnson, Christina — Medical University of South Carolina
- Study coordinator: Voelkel-Johnson, Christina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.