Identifying key immune targets for malaria vaccines
Defining conserved epitopes on polymorphic malaria antigens
This study is looking at how our immune system can better fight malaria by finding parts of the malaria parasite that can help create strong antibodies, especially in young children who are most at risk, to help develop a vaccine that works against different types of malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11010740 on NIH RePORTER |
What this research studies
This research focuses on understanding how the immune system can effectively respond to malaria by identifying conserved regions on malaria antigens that can trigger a protective antibody response. The study aims to analyze the immune responses of individuals living in malaria-endemic regions to determine which specific parts of the malaria parasite are most effective at eliciting immunity. By identifying these conserved epitopes, the research seeks to inform the design of a malaria vaccine that can provide broad protection against various strains of the parasite, particularly in young children who are most vulnerable to severe disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include young children living in malaria-endemic regions who are at high risk for malaria infection.
Not a fit: Patients who are not living in malaria-endemic areas or who are already immune to malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective malaria vaccine, significantly reducing the incidence of malaria in children.
How similar studies have performed: Previous research has shown promise in identifying conserved epitopes for other infectious diseases, suggesting that this approach could be effective for malaria as well.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Bunnik, Evelien Margaretha — University of Texas Hlth Science Center
- Study coordinator: Bunnik, Evelien Margaretha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.