Identifying key immune responses to develop a vaccine for Kaposi sarcoma-associated herpesvirus.
Official title: Defining Critical Sites of Vulnerability and Correlates of Protection to Kaposi Sarcoma Associated Herpesvirus to Inform Vaccine Design
Funded at Fred Hutchinson Cancer Center · NIH-11003468 · Data updated 2026-11-12
This study is looking at how the immune system reacts to a virus linked to certain cancers, especially in people with HIV, to help develop a vaccine that could protect against it.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $767,691 |
| NIH project number | 1U01CA295050-01 |
| Project ID | NIH-11003468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who are infected with KSHV, particularly those in sub-Saharan Africa or men who have sex with men.
✕Less likely to help
Patients who are not infected with KSHV or those without HIV may not benefit from this research.
What this research studies
This research aims to understand how the immune system responds to Kaposi sarcoma-associated herpesvirus (KSHV), which is linked to serious conditions like Kaposi sarcoma and lymphoma, particularly in individuals with HIV. By analyzing blood samples from people infected with KSHV, the researchers will identify specific immune responses that could be targeted by a vaccine. They will also study how neutralizing antibodies can protect against KSHV infection using animal models. The goal is to define the necessary immune responses for an effective vaccine.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that prevents KSHV infection and reduces the incidence of related cancers in vulnerable populations.
How similar studies have gone: Previous research has shown promise in developing vaccines targeting other oncogenic viruses, suggesting potential for success in this area as well.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Mcguire, Andrew — Fred Hutchinson Cancer Center
- Study coordinator: Mcguire, Andrew
Related research
Other NIH-funded projects on the same topics.
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Precision 3D Imaging to Monitor Kaposi Sarcoma (KS) with SkinScan3D
A new portable 3D imaging tool called SkinScan3D will help doctors measure KS skin lesions more accurately and quickly, especially in people living with HIV.
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Precision 3D Imaging to Track Kaposi Sarcoma (KS) with SkinScan3D
A new 3D imaging tool called SkinScan3D helps doctors monitor Kaposi sarcoma lesions more accurately and quickly, especially in settings with high KS burden like East Africa and in U.S. clinics with HIV patients.
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Kaposi Sarcoma care and research in Africa during ART era
A collaborative program to better understand and improve diagnosis, treatment, and prevention of Kaposi sarcoma for people living with HIV in Zambia and Tanzania.
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Kaposi Sarcoma in Africa: ART Era Research Network
A collaborative program in Africa and the United States will study Kaposi sarcoma in people living with HIV on ART to improve diagnosis, treatment, and prevention.
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Kaposi Sarcoma in Africa in the ART Era
This grant supports research to improve how Kaposi sarcoma is detected, treated, and understood in people living with HIV in Zambia and Tanzania during ART, with collaboration between African hospitals and a U.S. center.
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Faster detection and connection to care for people with HIV who develop Kaposi sarcoma in East Africa
This project aims to speed up finding people with HIV diagnosed with Kaposi sarcoma in East Africa and help them get linked to care more quickly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.