Identifying key genes involved in Alzheimer's Disease through advanced cell analysis techniques
Uncovering cell-type-specific driver genes of Alzheimer's Disease by pathology-indexing scRNA-seq, spatial transcriptomics, and CRISPR screens
This study is looking at how different kinds of damage in brain cells relate to Alzheimer's Disease, using special techniques to understand how these changes affect the brain, with the hope of finding new treatments that could help patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11076263 on NIH RePORTER |
What this research studies
This research investigates how different types of cellular damage contribute to Alzheimer's Disease by analyzing individual brain cells. It uses advanced techniques like single-cell RNA sequencing and spatial transcriptomics to understand how various pathologies affect different cell types in the brain. By cataloging these effects, the research aims to identify specific genes that drive the progression of Alzheimer's, which could lead to new treatment strategies. Patients may benefit from insights gained about their specific condition and potential targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease or those exhibiting symptoms of cognitive decline.
Not a fit: Patients with other forms of dementia that are not related to Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Alzheimer's Disease by identifying specific genetic targets for intervention.
How similar studies have performed: Previous research has shown promise in using similar advanced techniques to uncover genetic factors in neurodegenerative diseases, suggesting a potential for success in this approach.
Where this research is happening
Chicago, United States
- Rush University Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Wang, Yanling — Rush University Medical Center
- Study coordinator: Wang, Yanling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.