Identifying key genes for malaria parasite development
Discovering the Essential Genome of Plasmodium Falciparum
This study is looking at the important genes of the malaria parasite that affect how it grows in the blood, especially in children and pregnant women in sub-Saharan Africa, to help find new ways to treat or prevent malaria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11125017 on NIH RePORTER |
What this research studies
This research focuses on understanding the essential genes of the malaria-causing parasite Plasmodium falciparum, particularly how these genes contribute to the development of the parasite's sexual stages within human blood cells. By using advanced genetic techniques, the researchers aim to identify which genes are crucial for the parasite's lifecycle, especially in children and pregnant women in sub-Saharan Africa. The study involves creating a library of genetically modified parasites to observe their development and behavior, which will help in pinpointing targets for new treatments or vaccines against malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old living in sub-Saharan Africa who are at risk of malaria infection.
Not a fit: Patients who are not in the targeted age group or geographic region, or those who do not have malaria, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating malaria, significantly reducing morbidity and mortality in affected populations.
How similar studies have performed: Previous research has shown promise in using genetic approaches to understand malaria, indicating that this method could yield valuable insights.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Adams, John H — University of South Florida
- Study coordinator: Adams, John H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.