Identifying key cells and genes in children with severe organ failure needing life support
Single cell multi-omics approaches in identifying driving cells and genes in pediatric MODS patients requiring ECMO support
This study is looking at how certain cells and genes affect children with multiple organ dysfunction syndrome who need special breathing support, with the hope of finding better ways to diagnose and treat them in the hospital.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10807354 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex cellular and molecular mechanisms behind multiple organ dysfunction syndrome (MODS) in pediatric patients who require extracorporeal membrane oxygenation (ECMO) support. By employing advanced single-cell multi-omics techniques and machine learning, the study aims to identify specific cells and genes that contribute to the deterioration of these patients. The goal is to develop innovative diagnostic and therapeutic methods that could improve outcomes for children in intensive care units. This approach builds on previous findings related to immune response dysregulation and epigenetic variations in MODS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients experiencing multiple organ dysfunction syndrome who are on ECMO support.
Not a fit: Patients who do not have MODS or are not on ECMO support may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for children suffering from severe organ failure.
How similar studies have performed: Previous research has shown promise in using big data approaches to identify biomarkers in pediatric diseases, suggesting potential for success with this novel multi-omics approach.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Shankar, Rama — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Shankar, Rama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.