Identifying important mutations in non-coding regions of multiple myeloma
Identifying and characterizing functional noncoding mutations in multiple myeloma
This study is looking at changes in certain parts of DNA that might help us understand how multiple myeloma, a type of blood cancer, develops, and it’s for patients who want to learn more about what might be happening in their bodies and how we can improve treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-11056029 on NIH RePORTER |
What this research studies
This research investigates mutations in non-coding regions of DNA that may influence the development of multiple myeloma, a type of blood cancer. By using advanced techniques like whole-genome sequencing and bisulfite sequencing, the study aims to identify specific mutations that affect gene regulation. Patients' tumor samples will be compared to their non-cancerous blood cells to pinpoint mutations that could play a role in cancer progression. The goal is to better understand how these mutations contribute to the disease and potentially identify new targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple myeloma, particularly those with specific molecular subtypes of the disease.
Not a fit: Patients with non-cancerous conditions or those without a diagnosis of multiple myeloma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors driving multiple myeloma, potentially improving treatment strategies.
How similar studies have performed: Previous research has shown promise in identifying functional mutations in non-coding regions in other cancers, suggesting that this approach could yield valuable insights.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Tycko, Benjamin — Hackensack University Medical Center
- Study coordinator: Tycko, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.